diff --git a/core/art_config.mk b/core/art_config.mk
index 1ea05db2c3..f47a8e21f7 100644
--- a/core/art_config.mk
+++ b/core/art_config.mk
@@ -44,3 +44,17 @@ else
 endif
 
 ADDITIONAL_PRODUCT_PROPERTIES += ro.dalvik.vm.enable_uffd_gc=$(ENABLE_UFFD_GC)
+
+# Create APEX_BOOT_JARS_EXCLUDED which is a list of jars to be removed from
+# ApexBoorJars when built from mainline prebuilts.
+# soong variables indicate whether the prebuilt is enabled:
+# - $(m)_module/source_build for art and TOGGLEABLE_PREBUILT_MODULES
+# - ANDROID/module_build_from_source for other mainline modules
+APEX_BOOT_JARS_EXCLUDED :=
+$(foreach pair, $(PRODUCT_APEX_BOOT_JARS_FOR_SOURCE_BUILD_ONLY),\
+  $(eval m := $(subst com.android.,,$(call word-colon,1,$(pair)))) \
+  $(if $(call soong_config_get,$(m)_module,source_build), \
+    $(if $(filter true,$(call soong_config_get,$(m)_module,source_build)),, \
+      $(eval APEX_BOOT_JARS_EXCLUDED += $(pair))), \
+    $(if $(filter true,$(call soong_config_get,ANDROID,module_build_from_source)),, \
+      $(eval APEX_BOOT_JARS_EXCLUDED += $(pair)))))
diff --git a/core/dex_preopt_config.mk b/core/dex_preopt_config.mk
index badf189fb3..10fbe8f184 100644
--- a/core/dex_preopt_config.mk
+++ b/core/dex_preopt_config.mk
@@ -94,7 +94,7 @@ ifeq ($(WRITE_SOONG_VARIABLES),true)
   $(call add_json_bool, DisableGenerateProfile,                  $(filter false,$(WITH_DEX_PREOPT_GENERATE_PROFILE)))
   $(call add_json_str,  ProfileDir,                              $(PRODUCT_DEX_PREOPT_PROFILE_DIR))
   $(call add_json_list, BootJars,                                $(PRODUCT_BOOT_JARS))
-  $(call add_json_list, ApexBootJars,                            $(PRODUCT_APEX_BOOT_JARS))
+  $(call add_json_list, ApexBootJars,                            $(filter-out $(APEX_BOOT_JARS_EXCLUDED), $(PRODUCT_APEX_BOOT_JARS)))
   $(call add_json_list, ArtApexJars,                             $(filter $(PRODUCT_BOOT_JARS),$(ART_APEX_JARS)))
   $(call add_json_list, TestOnlyArtBootImageJars,                $(PRODUCT_TEST_ONLY_ART_BOOT_IMAGE_JARS))
   $(call add_json_list, SystemServerJars,                        $(PRODUCT_SYSTEM_SERVER_JARS))
diff --git a/core/soong_config.mk b/core/soong_config.mk
index e39f2fa72f..08e9a653ab 100644
--- a/core/soong_config.mk
+++ b/core/soong_config.mk
@@ -164,7 +164,7 @@ $(call add_json_bool, UncompressPrivAppDex,              $(call invert_bool,$(fi
 $(call add_json_list, ModulesLoadedByPrivilegedModules,  $(PRODUCT_LOADED_BY_PRIVILEGED_MODULES))
 
 $(call add_json_list, BootJars,                          $(PRODUCT_BOOT_JARS))
-$(call add_json_list, ApexBootJars,                      $(PRODUCT_APEX_BOOT_JARS))
+$(call add_json_list, ApexBootJars,                      $(filter-out $(APEX_BOOT_JARS_EXCLUDED), $(PRODUCT_APEX_BOOT_JARS)))
 
 $(call add_json_bool, VndkUseCoreVariant,                $(TARGET_VNDK_USE_CORE_VARIANT))
 $(call add_json_bool, VndkSnapshotBuildArtifacts,        $(VNDK_SNAPSHOT_BUILD_ARTIFACTS))
diff --git a/target/product/default_art_config.mk b/target/product/default_art_config.mk
index 3f2376dd4b..56b1946330 100644
--- a/target/product/default_art_config.mk
+++ b/target/product/default_art_config.mk
@@ -57,6 +57,8 @@ PRODUCT_BOOT_JARS += \
     ims-common
 
 # APEX boot jars. Keep the list sorted by module names and then library names.
+# Note: If the existing apex introduces the new jar, also add it to
+# PRODUCT_APEX_BOOT_JARS_FOR_SOURCE_BUILD_ONLY below.
 # Note: core-icu4j is moved back to PRODUCT_BOOT_JARS in product_config.mk at a later stage.
 # Note: For modules available in Q, DO NOT add new entries here.
 PRODUCT_APEX_BOOT_JARS := \
@@ -85,6 +87,12 @@ PRODUCT_APEX_BOOT_JARS := \
     com.android.virt:framework-virtualization \
     com.android.wifi:framework-wifi \
 
+# TODO(b/308174306): Adjust this after multiple prebuilts version is supported.
+# APEX boot jars that are not in prebuilt apexes.
+# Keep the list sorted by module names and then library names.
+PRODUCT_APEX_BOOT_JARS_FOR_SOURCE_BUILD_ONLY := \
+    com.android.mediaprovider:framework-pdf \
+
 # List of system_server classpath jars delivered via apex.
 # Keep the list sorted by module names and then library names.
 # Note: For modules available in Q, DO NOT add new entries here.