diff --git a/tools/releasetools/Android.bp b/tools/releasetools/Android.bp
index 11f92abb17..d26678d56e 100644
--- a/tools/releasetools/Android.bp
+++ b/tools/releasetools/Android.bp
@@ -104,6 +104,12 @@ python_defaults {
         "brillo_update_payload",
         "checkvintf",
     ],
+    target: {
+        darwin: {
+            // required module "brillo_update_payload" is disabled on darwin
+            enabled: false,
+        },
+    },
 }
 
 //
@@ -297,6 +303,12 @@ python_binary_host {
     required: [
         "delta_generator",
     ],
+    target: {
+        darwin: {
+            // required module "delta_generator" is disabled on darwin
+            enabled: false,
+        },
+    },
 }
 
 python_binary_host {
@@ -369,6 +381,12 @@ python_binary_host {
     required: [
         "checkvintf",
     ],
+    target: {
+        darwin: {
+            // libs dep "releasetools_ota_from_target_files" is disabled on darwin
+            enabled: false,
+        },
+    },
 }
 
 python_binary_host {
@@ -466,6 +484,12 @@ python_defaults {
     data: [
         "testdata/**/*",
     ],
+    target: {
+        darwin: {
+            // libs dep "releasetools_ota_from_target_files" is disabled on darwin
+            enabled: false,
+        },
+    },
 }
 
 python_test_host {