diff --git a/android/config.go b/android/config.go
index 52a8f13f8..f430b7215 100644
--- a/android/config.go
+++ b/android/config.go
@@ -541,7 +541,30 @@ func (c *config) IsMixedBuildsEnabled() bool {
 			fmt.Fprintln(os.Stderr, "unsupported device arch 'riscv64' for Bazel: falling back to non-mixed build")
 			return false
 		}
-		// TODO(b/253664931): Add other fallback criteria below.
+		if c.IsEnvTrue("GLOBAL_THINLTO") {
+			fmt.Fprintln(os.Stderr, "unsupported env var GLOBAL_THINLTO for Bazel: falling back to non-mixed build")
+			return false
+		}
+		if c.IsEnvTrue("CLANG_COVERAGE") {
+			fmt.Fprintln(os.Stderr, "unsupported env var CLANG_COVERAGE for Bazel: falling back to non-mixed build")
+			return false
+		}
+		if len(c.productVariables.SanitizeHost) > 0 {
+			fmt.Fprintln(os.Stderr, "unsupported product var SanitizeHost for Bazel: falling back to non-mixed build")
+			return false
+		}
+		if len(c.productVariables.SanitizeDevice) > 0 {
+			fmt.Fprintln(os.Stderr, "unsupported product var SanitizeDevice for Bazel: falling back to non-mixed build")
+			return false
+		}
+		if len(c.productVariables.SanitizeDeviceDiag) > 0 {
+			fmt.Fprintln(os.Stderr, "unsupported product var SanitizeDeviceDiag for Bazel: falling back to non-mixed build")
+			return false
+		}
+		if len(c.productVariables.SanitizeDeviceArch) > 0 {
+			fmt.Fprintln(os.Stderr, "unsupported product var SanitizeDeviceArch for Bazel: falling back to non-mixed build")
+			return false
+		}
 		return true
 	}).(bool)