diff --git a/android/module.go b/android/module.go
index 19502bae8..f9ea89778 100644
--- a/android/module.go
+++ b/android/module.go
@@ -1371,7 +1371,7 @@ func (attrs *CommonAttributes) fillCommonBp2BuildModuleAttrs(ctx *topDownMutator
 		for _, axis := range enabledPropertyOverrides.SortedConfigurationAxes() {
 			configToBools := enabledPropertyOverrides.ConfigurableValues[axis]
 			for cfg, val := range configToBools {
-				if axis != bazel.OsConfigurationAxis || osSupport[cfg] {
+				if axis != bazel.OsConfigurationAxis || osSupport[cfg] || val /*If enabled is explicitly requested via overrides */ {
 					enabledProperty.SetSelectValue(axis, cfg, &val)
 				}
 			}
diff --git a/android/proto.go b/android/proto.go
index 7c418c693..fc21d0177 100644
--- a/android/proto.go
+++ b/android/proto.go
@@ -408,6 +408,11 @@ func createProtoLibraryTargetsForIncludeDirs(ctx Bp2buildMutatorContext, include
 			// As a workarounds, delete `target_compatible_with`
 			alwaysEnabled := bazel.BoolAttribute{}
 			alwaysEnabled.Value = proptools.BoolPtr(true)
+			// Add android and linux explicitly so that fillcommonbp2buildmoduleattrs can override these configs
+			// When we extend b support for other os'es (darwin/windows), we should add those configs here as well
+			alwaysEnabled.SetSelectValue(bazel.OsConfigurationAxis, bazel.OsAndroid, proptools.BoolPtr(true))
+			alwaysEnabled.SetSelectValue(bazel.OsConfigurationAxis, bazel.OsLinux, proptools.BoolPtr(true))
+
 			ctx.CreateBazelTargetModuleWithRestrictions(
 				bazel.BazelTargetModuleProperties{Rule_class: "proto_library"},
 				CommonAttributes{
diff --git a/bp2build/cc_library_conversion_test.go b/bp2build/cc_library_conversion_test.go
index 02ed57a51..e50c710d2 100644
--- a/bp2build/cc_library_conversion_test.go
+++ b/bp2build/cc_library_conversion_test.go
@@ -5241,3 +5241,41 @@ func TestProtoLocalIncludeDirs(t *testing.T) {
 	}
 	runCcLibraryTestCase(t, tc)
 }
+
+// `foo_device` and `bar_host` can depend on .proto files of a specific dir,
+// the dynamically generated proto_library should not have any target_compatible_with
+func TestProtoLibraryForIncludeDirsIsOsAgnostic(t *testing.T) {
+	tc := Bp2buildTestCase{
+		Description:                "proto_library generated for proto.include_dirs is compatible for all axes",
+		ModuleTypeUnderTest:        "cc_library",
+		ModuleTypeUnderTestFactory: cc.LibraryFactory,
+		Blueprint: simpleModuleDoNotConvertBp2build("cc_library", "libprotobuf-cpp-lite") + `
+cc_library {
+	name: "foo_device",
+	device_supported: true, // this is the default behavior, but added explicitly here for illustration
+	host_supported: false,
+	proto: {include_dirs: ["dir"]},
+}
+cc_library {
+	name: "bar_host",
+	device_supported: false,
+	host_supported: true,
+	srcs: ["bar.proto"],
+	proto: {include_dirs: ["dir"]},
+}
+`,
+		Filesystem: map[string]string{
+			"dir/Android.bp": "",
+			"dir/dir.proto":  "",
+		},
+		Dir: "dir", // check for the generated proto_library
+		ExpectedBazelTargets: []string{
+			MakeBazelTargetNoRestrictions("proto_library", "dir.include_dir_bp2build_generated_proto", AttrNameToString{
+				"srcs":                `["dir.proto"]`,
+				"strip_import_prefix": `""`,
+				"tags":                `["manual"]`,
+			}),
+		},
+	}
+	runCcLibraryTestCase(t, tc)
+}