diff --git a/apex/apex.go b/apex/apex.go
index 2f8a925e9..6490b83ee 100644
--- a/apex/apex.go
+++ b/apex/apex.go
@@ -846,10 +846,13 @@ func RegisterPostDepsMutators(ctx android.RegisterMutatorsContext) {
 // Mark the direct and transitive dependencies of apex bundles so that they
 // can be built for the apex bundles.
 func apexDepsMutator(mctx android.TopDownMutatorContext) {
+	if !mctx.Module().Enabled() {
+		return
+	}
 	var apexBundles []android.ApexInfo
 	var directDep bool
 	if a, ok := mctx.Module().(*apexBundle); ok && !a.vndkApex {
-		apexBundles = []android.ApexInfo{android.ApexInfo{
+		apexBundles = []android.ApexInfo{{
 			ApexName:      mctx.ModuleName(),
 			MinSdkVersion: a.minSdkVersion(mctx),
 		}}
@@ -887,6 +890,9 @@ func inAnySdk(module android.Module) bool {
 
 // Create apex variations if a module is included in APEX(s).
 func apexMutator(mctx android.BottomUpMutatorContext) {
+	if !mctx.Module().Enabled() {
+		return
+	}
 	if am, ok := mctx.Module().(android.ApexModule); ok && am.CanHaveApexVariants() {
 		am.CreateApexVariations(mctx)
 	} else if a, ok := mctx.Module().(*apexBundle); ok && !a.vndkApex {
@@ -924,6 +930,9 @@ func addFlattenedFileContextsInfos(ctx android.BaseModuleContext, fileContextsIn
 }
 
 func apexFlattenedMutator(mctx android.BottomUpMutatorContext) {
+	if !mctx.Module().Enabled() {
+		return
+	}
 	if ab, ok := mctx.Module().(*apexBundle); ok {
 		var variants []string
 		switch proptools.StringDefault(ab.properties.Payload_type, "image") {
diff --git a/apex/apex_test.go b/apex/apex_test.go
index ab6d07408..95d7afbf6 100644
--- a/apex/apex_test.go
+++ b/apex/apex_test.go
@@ -4205,6 +4205,27 @@ func TestApexWithJniLibs(t *testing.T) {
 	})
 }
 
+func TestApexMutatorsDontRunIfDisabled(t *testing.T) {
+	ctx, _ := testApex(t, `
+		apex {
+			name: "myapex",
+			key: "myapex.key",
+		}
+		apex_key {
+			name: "myapex.key",
+			public_key: "testkey.avbpubkey",
+			private_key: "testkey.pem",
+		}
+	`, func(fs map[string][]byte, config android.Config) {
+		delete(config.Targets, android.Android)
+		config.AndroidCommonTarget = android.Target{}
+	})
+
+	if expected, got := []string{""}, ctx.ModuleVariantsForTests("myapex"); !reflect.DeepEqual(expected, got) {
+		t.Errorf("Expected variants: %v, but got: %v", expected, got)
+	}
+}
+
 func TestApexWithJniLibs_Errors(t *testing.T) {
 	testApexError(t, `jni_libs: "xxx" is not a cc_library`, `
 		apex {